Mouse models
Recent articles
Diverse autism genes derail common developmental pathways
Multiple genetic mouse models initially show delayed cortical development, but the animals’ molecular trajectories diverge within weeks after birth, a new study finds.
Diverse autism genes derail common developmental pathways
Multiple genetic mouse models initially show delayed cortical development, but the animals’ molecular trajectories diverge within weeks after birth, a new study finds.
Noncoding RNA sways core autism traits in mice
Small deletions in an X-linked RNA alter social and repetitive behaviors in male mice without broadly affecting learning or memory.
Noncoding RNA sways core autism traits in mice
Small deletions in an X-linked RNA alter social and repetitive behaviors in male mice without broadly affecting learning or memory.
Embrace complexity to improve the translatability of basic neuroscience
Researchers must learn to view heterogeneity as an essential feature of the systems they study and a central consideration in experimental design, not a variable to control for or reduce.
Embrace complexity to improve the translatability of basic neuroscience
Researchers must learn to view heterogeneity as an essential feature of the systems they study and a central consideration in experimental design, not a variable to control for or reduce.
Taking a closer look at astrocytes and autism
These glial cells are increasingly linked to neurodevelopmental conditions and the regulation of social behaviors and anxiety.
Taking a closer look at astrocytes and autism
These glial cells are increasingly linked to neurodevelopmental conditions and the regulation of social behaviors and anxiety.
Astrocytes orchestrate oxytocin’s social effects in mice
The cells amplify oxytocin—and may be responsible for sex differences in social behavior, two preprints find.
Astrocytes orchestrate oxytocin’s social effects in mice
The cells amplify oxytocin—and may be responsible for sex differences in social behavior, two preprints find.
Aging neurons outsource garbage disposal, clog microglia
Degradation-resistant proteins pass from neurons to glial cells in a process that may spread protein clumps around the brain, according to a study in mice.
Aging neurons outsource garbage disposal, clog microglia
Degradation-resistant proteins pass from neurons to glial cells in a process that may spread protein clumps around the brain, according to a study in mice.
Snoozing dragons stir up ancient evidence of sleep’s dual nature
Deep-sleep cycling between brain waves of higher and lower amplitude dates far back on the evolutionary tree, according to a new comparative study of mammals and reptiles.
Snoozing dragons stir up ancient evidence of sleep’s dual nature
Deep-sleep cycling between brain waves of higher and lower amplitude dates far back on the evolutionary tree, according to a new comparative study of mammals and reptiles.
Gene replacement therapy normalizes some traits in SYNGAP1 model mice
The first published virus-based gene therapy for SYNGAP1 deletion yields benefits despite the gene’s long length and complexity.
Gene replacement therapy normalizes some traits in SYNGAP1 model mice
The first published virus-based gene therapy for SYNGAP1 deletion yields benefits despite the gene’s long length and complexity.
Constellation of studies charts brain development, offers ‘dramatic revision’
The atlases could pinpoint pathways that determine the fate of cells linked to neurodevelopmental conditions.
Constellation of studies charts brain development, offers ‘dramatic revision’
The atlases could pinpoint pathways that determine the fate of cells linked to neurodevelopmental conditions.
Protein tug-of-war controls pace of synaptic development, sets human brains apart
Human-specific duplicates of SRGAP2 prolong cortical development by manipulating SYNGAP, an autism-linked protein that slows synaptic growth.
Protein tug-of-war controls pace of synaptic development, sets human brains apart
Human-specific duplicates of SRGAP2 prolong cortical development by manipulating SYNGAP, an autism-linked protein that slows synaptic growth.
Explore more from The Transmitter
An Iranian, an Israeli, and a Palestinian neuroscientist walked into a bar…
That chance occurrence at an SfN social led us to organize the Middle Eastern Systems Neuroscience Symposium, and forge a plan to build a community that transcends political barriers through scientific connection.
An Iranian, an Israeli, and a Palestinian neuroscientist walked into a bar…
That chance occurrence at an SfN social led us to organize the Middle Eastern Systems Neuroscience Symposium, and forge a plan to build a community that transcends political barriers through scientific connection.
Federal advisory panel extends comment period, and more
Here is a roundup of autism-related news and research spotted around the web for the week of 27 July.
Federal advisory panel extends comment period, and more
Here is a roundup of autism-related news and research spotted around the web for the week of 27 July.
Oregon primate research center to downsize monkey colony, pivot to non-animal models
The center’s host university had been negotiating with the federal government about converting the center into an animal sanctuary. A new plan, approved today, preserves some of the center’s nonhuman primate studies.
Oregon primate research center to downsize monkey colony, pivot to non-animal models
The center’s host university had been negotiating with the federal government about converting the center into an animal sanctuary. A new plan, approved today, preserves some of the center’s nonhuman primate studies.