Mouse models
Recent articles
Noncoding RNA sways core autism traits in mice
Small deletions in an X-linked RNA alter social and repetitive behaviors in male mice without broadly affecting learning or memory.
Noncoding RNA sways core autism traits in mice
Small deletions in an X-linked RNA alter social and repetitive behaviors in male mice without broadly affecting learning or memory.
Embrace complexity to improve the translatability of basic neuroscience
Researchers must learn to view heterogeneity as an essential feature of the systems they study and a central consideration in experimental design, not a variable to control for or reduce.
Embrace complexity to improve the translatability of basic neuroscience
Researchers must learn to view heterogeneity as an essential feature of the systems they study and a central consideration in experimental design, not a variable to control for or reduce.
Taking a closer look at astrocytes and autism
These glial cells are increasingly linked to neurodevelopmental conditions and the regulation of social behaviors and anxiety.
Taking a closer look at astrocytes and autism
These glial cells are increasingly linked to neurodevelopmental conditions and the regulation of social behaviors and anxiety.
Astrocytes orchestrate oxytocin’s social effects in mice
The cells amplify oxytocin—and may be responsible for sex differences in social behavior, two preprints find.
Astrocytes orchestrate oxytocin’s social effects in mice
The cells amplify oxytocin—and may be responsible for sex differences in social behavior, two preprints find.
Aging neurons outsource garbage disposal, clog microglia
Degradation-resistant proteins pass from neurons to glial cells in a process that may spread protein clumps around the brain, according to a study in mice.
Aging neurons outsource garbage disposal, clog microglia
Degradation-resistant proteins pass from neurons to glial cells in a process that may spread protein clumps around the brain, according to a study in mice.
Snoozing dragons stir up ancient evidence of sleep’s dual nature
Deep-sleep cycling between brain waves of higher and lower amplitude dates far back on the evolutionary tree, according to a new comparative study of mammals and reptiles.
Snoozing dragons stir up ancient evidence of sleep’s dual nature
Deep-sleep cycling between brain waves of higher and lower amplitude dates far back on the evolutionary tree, according to a new comparative study of mammals and reptiles.
Gene replacement therapy normalizes some traits in SYNGAP1 model mice
The first published virus-based gene therapy for SYNGAP1 deletion yields benefits despite the gene’s long length and complexity.
Gene replacement therapy normalizes some traits in SYNGAP1 model mice
The first published virus-based gene therapy for SYNGAP1 deletion yields benefits despite the gene’s long length and complexity.
Constellation of studies charts brain development, offers ‘dramatic revision’
The atlases could pinpoint pathways that determine the fate of cells linked to neurodevelopmental conditions.
Constellation of studies charts brain development, offers ‘dramatic revision’
The atlases could pinpoint pathways that determine the fate of cells linked to neurodevelopmental conditions.
Protein tug-of-war controls pace of synaptic development, sets human brains apart
Human-specific duplicates of SRGAP2 prolong cortical development by manipulating SYNGAP, an autism-linked protein that slows synaptic growth.
Protein tug-of-war controls pace of synaptic development, sets human brains apart
Human-specific duplicates of SRGAP2 prolong cortical development by manipulating SYNGAP, an autism-linked protein that slows synaptic growth.
Boosting SCN2A expression reduces seizures in mice
A modified form of CRISPR amps up expression of the gene—a strategy that could apply to other gene variations linked to autism.
Boosting SCN2A expression reduces seizures in mice
A modified form of CRISPR amps up expression of the gene—a strategy that could apply to other gene variations linked to autism.
Explore more from The Transmitter
When autistic kids grow up, Chapter 3: Would there be data?
Tempest McDonald takes a postdoctoral position at Vanderbilt University. Researching her paper accusing the National Institutes of Health of discrimination threatens everything she has built.
When autistic kids grow up, Chapter 3: Would there be data?
Tempest McDonald takes a postdoctoral position at Vanderbilt University. Researching her paper accusing the National Institutes of Health of discrimination threatens everything she has built.
Cousin comparison parses genetic effects in autism
The approach helps reveal whether maternal genes contribute directly to autism in children or have indirect effects on the prenatal environment.
Cousin comparison parses genetic effects in autism
The approach helps reveal whether maternal genes contribute directly to autism in children or have indirect effects on the prenatal environment.
Single-neuron recordings zoom into ‘blurry map’ of human motor cortex
The motor cortex is organized into an "intermixed jumble of tiles" to generate meaningful movement.
Single-neuron recordings zoom into ‘blurry map’ of human motor cortex
The motor cortex is organized into an "intermixed jumble of tiles" to generate meaningful movement.