X chromosome
Accounting for a mosaic of sex differences: Q&A with Nicola Grissom
Breaking the binary view of sex traits can enable researchers to represent the broader complexity of behavior and cognition.
![](https://www.thetransmitter.org/wp-content/uploads/2024/07/1200_GenderQA-1-1024x692.png)
Accounting for a mosaic of sex differences: Q&A with Nicola Grissom
Breaking the binary view of sex traits can enable researchers to represent the broader complexity of behavior and cognition.
Turner syndrome tied to autism
Most people with the X-linked syndrome have autism traits, and about one-quarter meet diagnostic criteria for the condition.
![Two teenage girls sit next to each other on a couch, one looking at a cell phone while the other uses a tablet computer.](https://www.thetransmitter.org/wp-content/uploads/2023/01/202301-Mental-health-female-autism-844.jpg)
Turner syndrome tied to autism
Most people with the X-linked syndrome have autism traits, and about one-quarter meet diagnostic criteria for the condition.
Silenced X chromosome genes reawaken in new mouse model
The new animal line could accelerate the discovery of gene-activating therapies for the autism-linked condition Rett syndrome.
![](https://www.thetransmitter.org/wp-content/uploads/2022/03/epigenetics_844.png)
Silenced X chromosome genes reawaken in new mouse model
The new animal line could accelerate the discovery of gene-activating therapies for the autism-linked condition Rett syndrome.
Huda Zoghbi: Taking genetic inquiry to the next level
Over the course of a career spanning more than three decades, Huda Zoghbi has won almost every major biology and neuroscience research award that exists. More than 20 years since she discovered the gene behind Rett syndrome, she remains laser focused on unlocking the condition’s secrets and finding effective treatments.
![Dr. Huda Zoghbi portrait](https://www.thetransmitter.org/wp-content/uploads/2021/06/DrZoghbiSideB844.jpg)
Huda Zoghbi: Taking genetic inquiry to the next level
Over the course of a career spanning more than three decades, Huda Zoghbi has won almost every major biology and neuroscience research award that exists. More than 20 years since she discovered the gene behind Rett syndrome, she remains laser focused on unlocking the condition’s secrets and finding effective treatments.
Alternative gene-therapy approaches take aim at Rett syndrome
Methods that selectively increase levels of the Rett protein make for safer and more effective treatment strategies, some researchers say.
![lab technician pipetting in dramatic light](https://www.thetransmitter.org/wp-content/uploads/2021/06/LabScenewide-844.jpg)
Alternative gene-therapy approaches take aim at Rett syndrome
Methods that selectively increase levels of the Rett protein make for safer and more effective treatment strategies, some researchers say.
Gene expression maps reveal origins of brain changes from autism mutations
A new study pinpoints the genes and cell types that may underlie the atypical brain structure seen in people with genetic conditions linked to autism.
![Brain images color-coded to show structural changes in autism.](https://www.thetransmitter.org/wp-content/uploads/2020/08/20200821-NeurogeneticDisorders-844b.jpg)
Gene expression maps reveal origins of brain changes from autism mutations
A new study pinpoints the genes and cell types that may underlie the atypical brain structure seen in people with genetic conditions linked to autism.
A quest for Quincy: Gene therapies come of age for some forms of autism
A gene therapy for Angelman syndrome stands at the forefront of efforts to treat autism-linked conditions that stem from single genes.
![Ralf Schmid, the research director in Neurodevelopmental diseases at the Gene Therapy Program Orphan Disease Center, loads replicated mouse dna into wells in the gel before applying electric current to test the viability of the dna.](https://www.thetransmitter.org/wp-content/uploads/2020/10/20201014-GTLablede844-1.jpg)
A quest for Quincy: Gene therapies come of age for some forms of autism
A gene therapy for Angelman syndrome stands at the forefront of efforts to treat autism-linked conditions that stem from single genes.
Method unravels Rett mutation’s effects on specific brain cells
A new technique may reveal how mutations on the X chromosome alter various types of cells in the brain.
![](https://www.thetransmitter.org/wp-content/uploads/2019/01/20190104-RettRNA-844jpg.jpg)
Method unravels Rett mutation’s effects on specific brain cells
A new technique may reveal how mutations on the X chromosome alter various types of cells in the brain.
New mouse model paves way for Rett syndrome treatments
A new line of female mice may enable researchers to test gene-based therapies for Rett syndrome.
![](https://www.thetransmitter.org/wp-content/uploads/2018/09/201808-RettMouse-844.jpg)
New mouse model paves way for Rett syndrome treatments
A new line of female mice may enable researchers to test gene-based therapies for Rett syndrome.
CRISPR tweak fixes genetic flaw in fragile X syndrome
A modified version of the genetic engineering tool CRISPR may restore expression of the gene mutated in fragile X syndrome.
![Deleting DNA repeats from fragile X neurons restores expression (right, red) of the gene silenced in the syndrome.](https://www.thetransmitter.org/wp-content/uploads/2017/03/Slide1rightpanels.jpg)
CRISPR tweak fixes genetic flaw in fragile X syndrome
A modified version of the genetic engineering tool CRISPR may restore expression of the gene mutated in fragile X syndrome.
Explore more from The Transmitter
New connectomes fly beyond the brain
Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.
![Research image of neurons in the fly’s ventral nerve cord.](https://www.thetransmitter.org/wp-content/uploads/2024/07/lede-motormodules-1200-1024x692.webp)
New connectomes fly beyond the brain
Researchers are mapping the neurons in Drosophila’s ventral nerve cord, where the central nervous system meets the rest of the body.
Building an autism research registry: Q&A with Tony Charman
A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.
![Illustration of researchers talking to laypeople amidst strands of DNA.](https://www.thetransmitter.org/wp-content/uploads/2024/07/1200_Charman-1024x687.webp)
Building an autism research registry: Q&A with Tony Charman
A purpose-built database of participants who have shared genomic and behavioral data could give clinical trials a boost, Charman says.
Cerebellar circuit may convert expected pain relief into real thing
The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.
![](https://www.thetransmitter.org/wp-content/uploads/2024/07/paincircuit-1200-1024x692.webp)
Cerebellar circuit may convert expected pain relief into real thing
The newly identified circuit taps into the brain’s opioid system to provide a top-down form of pain relief.